Archives 2021


The Blood-Brain Barrier, an Evolving Concept Based on Technological Advances and Cell-Cell Communications.

Menaceur C, Gosselet F, Fenart L, Saint-Pol J.

Cells. 2021 Dec 31;11(1):133.

PMID: 35011695

DOI:  10.3390/cells11010133


A Triple Culture Cell System Modeling the Human Blood-Brain Barrier.

Rizzi E, Deligne C, Dehouck L, Bilardo R, Sano Y, Shimizu F, Kanda T, Resmini M, Gosselet F, Dehouck MP, Mysiorek C.

J Vis Exp. 2021 Nov 30;(177).

PMID: 34927613

DOI: 10.3791/63134 


Secretome of endothelial progenitor cells from stroke patients promotes endothelial barrier tightness and protects against hypoxia-induced vascular leakage.

Loiola RA, García-Gabilondo M, Grayston A, Bugno P, Kowalska A, Duban-Deweer S, Rizzi E, Hachani J, Sano Y, Shimizu F, Kanda T, Mysiorek C, Mazurek MP, Rosell A, Gosselet F.

Stem Cell Res Ther. 2021 Oct 26;12(1):552.

PMID: 34702368

DOI:  10.1186/s13287-021-02608-y


Transport study of interleukin-1 inhibitors using a human in vitro model of the blood-brain barrier.

Sjöström EO, Culot M, Leickt L, Åstrand M, Nordling E, Gosselet F, Kaiser C.

Brain Behav Immun Health. 2021 Jul 31;16:100307.

PMID: 34589799

DOI:  10.1016/j.bbih.2021.100307


SARS-CoV-2 Poorly Replicates in Cells of the Human Blood-Brain Barrier Without Associated Deleterious Effects.

Constant O, Barthelemy J, Bolloré K, Tuaillon E, Gosselet F, Chable-Bessia C, Merida P, Muriaux D, Van de Perre P, Salinas S, Simonin Y.

Front Immunol. 2021 Jul 27;12:697329.

PMID: 34386007

DOI:  10.3389/fimmu.2021.697329


Antimalarial drug discovery: from quinine to the most recent promising clinical drug candidates.

Tisnerat C, Dassonville-Klimpt A, Gosselet F, Sonnet P.

Curr Med Chem. 2022;29(19):3326-3365.

PMID: 34344287

DOI:  10.2174/0929867328666210803152419


Potential neurotoxicity of titanium implants: Prospective, in-vivo and in-vitro study.

Shelly S, Liraz Zaltsman S, Ben-Gal O, Dayan A, Ganmore I, Shemesh C, Atrakchi D, Garra S, Ravid O, Rand D, Israelov H, Alon T, Lichtenstein G, Sharabi S, Last D, Gosselet F, Rosen V, Burstein G, Friedlander A, Harel R, Vogel G, Schnaider Beeri M, Mardor Y, Lampl Y, Fleminger G, Cooper I.

Biomaterials. 2021 Sep;276:121039.

PMID: 34352627

DOI:  10.1016/j.biomaterials.2021.121039


Application of in vitro data in physiologically-based kinetic models for quantitative in vitro-in vivo extrapolation: A case-study for baclofen.

Kasteel EEJ, Lautz LS, Culot M, Kramer NI, Zwartsen A.

Toxicol In Vitro. 2021 Oct;76:105223.

PMID: 34293430

DOI:  10.1016/j.tiv.2021.105223


Miniaturization and Automation of a Human In Vitro Blood–Brain Barrier Model for the High-Throughput Screening of Compounds in the Early Stage of Drug Discovery.

Moya ELJ, Vandenhaute E, Rizzi E, Boucau M-C, Hachani J, Maubon N, Gosselet F, Dehouck M-P.

Pharmaceutics. 2021 Jun 16;13(6):892.

PMID: 34208550

DOI:  10.3390/pharmaceutics13060892


Role of ABCA7 in Human Health and in Alzheimer's Disease.

Dib S, Pahnke J, Gosselet F.

Int J Mol Sci. 2021 Apr 27;22(9):4603.

PMID: 33925691

DOI:  10.3390/ijms22094603


Endothelial Iron Homeostasis Regulates Blood-Brain Barrier Integrity via the HIF2α-Ve-Cadherin Pathway.

Rand D, Ravid O, Atrakchi D, Israelov H, Bresler Y, Shemesh C, Omesi L, Liraz-Zaltsman S, Gosselet F, Maskrey TS, Beeri MS, Wipf P, Cooper I.

Pharmaceutics. 2021 Feb 28;13(3):311.

PMID: 33670876

DOI:  10.3390/pharmaceutics13030311


Discovery of pyrazolo-thieno[3,2-d]pyrimidinylamino-phenyl acetamides as type-II pan-tropomyosin receptor kinase (TRK) inhibitors: Design, synthesis, and biological evaluation.

Yan W, Zhang L, Lv F, Moccia M, Carlomagno F, Landry C, Santoro M, Gosselet F, Frett B, Li HY.

Eur J Med Chem. 2021 Feb 9;216:113265.

PMID: 33652352

DOI:  10.1016/j.ejmech.2021.113265


Evaluation of a human iPSC-derived BBB model for repeated dose toxicity testing with cyclosporine A as model compound.

Wellens S, Dehouck L, Chandrasekaran V, Singh P, Loiola RA, Sevin E, Exner T, Paul J, Gosselet F, Culot M.

Toxicol In Vitro. 2021 Jun;73:105112.

PMID: 33631201

DOI:  10.1016/j.tiv.2021.105112


Flow induces barrier and glycocalyx-related genes and negative surface charge in a lab-on-a-chip human blood-brain barrier model.

Santa-Maria AR, Walter FR, Figueiredo R, Kincses A, Vigh JP, Heymans M, Culot M, Winter P, Gosselet F, Dér A, Deli MA.

J Cereb Blood Flow Metab. 2021 Sep;41(9):2201-2215.

PMID: 33563079

DOI:  10.1177/0271678X21992638


Time-Dependent Internalization of Polymer-Coated Silica Nanoparticles in Brain Endothelial Cells and Morphological and Functional Effects on the Blood-Brain Barrier.

Bittner A, Gosselet F, Sevin E, Dehouck L, Ducray AD, Gaschen V, Stoffel MH, Cho H, Mevissen M.

Int J Mol Sci. 2021 Feb 6;22(4):1657.

PMID: 33562136

DOI:  10.3390/ijms22041657


Beyond the Rule of 5: Impact of PEGylation with Various Polymer Sizes on Pharmacokinetic Properties, Structure-Properties Relationships of mPEGylated Small Agonists of TGR5 Receptor.

Hoguet V, Lasalle M, Maingot M, Dequirez G, Boulahjar R, Leroux F, Piveteau C, Herledan A, Biela A, Dumont J, Chávez-Talavera O, Belloy L, Duplan I, Hennuyer N, Butruille L, Lestavel S, Sevin E, Culot M, Gosselet F, Staels B, Deprez B, Tailleux A, Charton J.

J Med Chem. 2021 Jan 20

PMID: 33470812

DOI:  10.1021/acs.jmedchem.0c01774


Differential neurovirulence of Usutu virus lineages in mice and neuronal cells.

Clé M, Constant O, Barthelemy J, Desmetz C, Martin MF, Lapeyre L, Cadar D, Savini G, Teodori L, Monaco F, Schmidt-Chanasit J, Saiz JC, Gonzales G, Lecollinet S, Beck C, Gosselet F, Van de Perre P, Foulongne V, Salinas S, Simonin Y.

J Neuroinflammation. 2021 Jan 6;18(1):11.

PMID: 33407600

DOI:  10.1186/s12974-020-02060-4


Central nervous system delivery of molecules across the blood-brain barrier.

Gosselet F, Loiola RA, Roig A, Rosell A, Culot M.

Neurochem Int. 2021 Mar;144:104952.

PMID: 33400964

DOI:  10.1016/j.neuint.2020.104952