Caspase-1 has a critical role in blood-brain barrier injury and its inhibition contributes to multifaceted repair.

Israelov H, Ravid O, Atrakchi D, Rand D, Elhaik S, Bresler Y, Twitto-Greenberg R, Omesi L, Liraz-Zaltsman S, Gosselet F, Schnaider Beeri M, Cooper I.

J Neuroinflammation. 2020 Sep 9;17(1):267.

PMID: 32907600


Naphthoquinone-Dopamine hybrids inhibit α-synuclein aggregation, disrupt preformed fibrils and attenuate aggregate-induced toxicity.

Paul A, Huber A, Rand D, Gosselet F, Cooper I, Gazit E, Segal D.

Chemistry. 2020 Sep 1. doi: 10.1002/chem.202003374.

PMID: 32870550


Advancing brain barriers RNA sequencing: guidelines from experimental design to publication.

Francisco DMF, Marchetti L, Rodríguez-Lorenzo S, Frías-Anaya E, Figueiredo RM; BtRAIN Network, Winter P, Romero IA, de Vries HE, Engelhardt B, Bruggmann R.

Fluids Barriers CNS. 2020 Aug 18;17(1):51

PMID: 32811511


Zika Virus Infection Promotes Local Inflammation, Cell Adhesion Molecule Upregulation, and Leukocyte Recruitment at the Blood-Brain Barrier.

Clé M, Desmetz C, Barthelemy J, Martin MF, Constant O, Maarifi G, Foulongne V, Bolloré K, Glasson Y, De Bock F, Blaquiere M, Dehouck L, Pirot N, Tuaillon E, Nisole S, Najioullah F, Van de Perre P, Cabié A, Marchi N, Gosselet F, Simonin Y, Salinas S.

mBio. 2020 Aug 4;11(4):e01183-20.

PMID : 32753493


Contribution of brain pericytes in blood-brain barrier formation and maintenance: a transcriptomic study of cocultured human endothelial cells derived from hematopoietic stem cells.

Heymans M, Figueiredo R, Dehouck L, Francisco D, Sano Y, Shimizu F, Kanda T, Bruggmann R, Engelhardt B, Winter P, Gosselet F, Culot M.

Fluids Barriers CNS. 2020 Jul 28;17(1):48.

PMID : 32723387


First step to the improvement of the blood brain barrier passage of atazanavir encapsulated in sustainable bioorganic vesicles.

Nolay F, Sevin E, Létévé M, Bil A, Gosselet F, Kirat KE, Djedaini-Pilard F, Morandat S, Fenart L, Przybylski C, Bonnet V.

Int J Pharm. 2020 Jul 11:119604.

PMID: 32663579


Chemoselective Hydrogenation of 6-alkynyl-3-fluoro-2-pyridinaldoxime: Access to first-in-class 6-alkyl-3-Fluoro-2-pyridinaldoxime as Reactivator of Sarin-Inhibited AChE with increased BBB Permeability.

Baati R, Jagadeesh Y, Dias J, Reddy Nimmakayala M, Courageux C, Gastellier AJ, Jegoux J, Coisne C, Landry C, Gosselet F, Hachani J, Goossens JF, Dehouck MP, Nachon F, Razafindrainibe F.

Chemistry. 2020 Jul 6. 

PMID: 32633095


Optimization of 2-DE and multiplexed detection of O-GlcNAcome, phosphoproteome and whole proteome protocol of synapse-associated proteins within the rat sensorimotor cortex.

Fourneau J, Cieniewski-Bernard C, Canu MH, Duban-Deweer S, Hachani J, Bastide B, Dupont E.

J Neurosci Methods. 2020 Jun 20:108807.

PMID: 32574643


Homology Modeling of the Human P-glycoprotein (ABCB1) and Insights into Ligand Binding through Molecular Docking Studies.  

Mora Lagares L, Minovski N, Caballero Alfonso AY, Benfenati E, Wellens S, Culot M, Gosselet F, Novič M.

Int J Mol Sci. 2020 Jun 5;21(11):E4058.

PMID: 32517082


Efficacy Assessment of an Uncharged Reactivator of NOP-Inhibited Acetylcholinesterase Based on Tetrahydroacridine Pyridine-Aldoxime Hybrid in Mouse Compared to Pralidoxime.

Calas AG, Hanak AS, Jaffré N, Nervo A, Dias J, Rousseau C, Courageux C, Brazzolotto X, Villa P, Obrecht A, Goossens JF, Landry C, Hachani J, Gosselet F, Dehouck MP, Yerri J, Kliachyna M, Baati R, Nachon F.

Biomolecules. 2020 Jun 4;10(6):E858.

PMID: 32512884


The Effect of Sodium Bicarbonate, a Beneficial Adjuvant Molecule in Cystic Fibrosis, on Bronchial Epithelial Cells Expressing a Wild-Type or Mutant CFTR Channel.

Gróf I, Bocsik A, Harazin A, Santa-Maria AR, Vizsnyiczai G, Barna L, Kiss L, Fűr G, Rakonczay Z Jr, Ambrus R, Szabó-Révész P, Gosselet F, Jaikumpun P, Szabó H, Zsembery Á, Deli MA.

Int J Mol Sci. 2020 Jun 4;21(11):E4024.

PMID: 32512832


Development of a human in vitro blood-brain tumor barrier model of diffuse intrinsic pontine glioma to better understand the chemoresistance.

Deligne C, Hachani J, Duban-Deweer S, Meignan S, Leblond P, Carcaboso AM, Sano Y, Shimizu F, Kanda T, Gosselet F, Dehouck MP, Mysiorek C.

Fluids Barriers CNS. 2020 Jun 2;17(1):37.

PMID : 32487241


GM1 Oligosaccharide Crosses the Human Blood-Brain Barrier In Vitro by a Paracellular Route.

Di Biase E, Lunghi G, Maggioni M, Fazzari M, Pomè DY, Loberto N, Ciampa MG, Fato P, Mauri L, Sevin E, Gosselet F, Sonnino S, Chiricozzi E.

Int J Mol Sci. 2020 Apr 19;21(8):E2858.

PMID : 32325905


Study of Usutu virus neuropathogenicity in mice and human cellular models.

Clé M, Barthelemy J, Desmetz C, Foulongne V, Lapeyre L, Bolloré K, Tuaillon E, Erkilic N, Kalatzis V, Lecollinet S, Beck C, Pirot N, Glasson Y, Gosselet F, Alvarez Martinez MT, Van de Perre P, Salinas S, Simonin Y.

PLoS Negl Trop Dis. 2020 Apr 23;14(4):e0008223.

PMID : 32324736


Serum-derived factors of breast cancer patients with brain metastases alter permeability of a human blood-brain barrier model.

Curtaz CJ, Schmitt C, Herbert SL, Feldheim J, Schlegel N, Gosselet F, Hagemann C, Roewer N, Meybohm P, Wöckel A, Burek M.

Fluids Barriers CNS. 2020 Apr 22;17(1):31.

PMID : 32321535


Targeting and Crossing the Blood-Brain Barrier with Extracellular Vesicles.

Saint-Pol J, Gosselet F, Duban-Deweer S, Pottiez G, Karamanos Y.

Cells. 2020 Apr 1;9(4).

PMID: 32244730


New Lipidyl-Cyclodextrins Obtained by Ring Opening of Methyl Oleate Epoxide Using Ball Milling.

Oliva E, Mathiron D, Rigaud S, Monflier E, Sevin E, Bricout H, Tilloy S, Gosselet F, Fenart L, Bonnet V, Pilard S, Djedaini-Pilard F.

Biomolecules. 2020 Feb 20;10(2). pii: E339.

Lien vers article : 32093153


PLGA protein nanocarriers with tailor-made fluorescence/MRI/PET imaging modalities.

Zhang Y, García-Gabilondo M, Grayston A, Feiner IVJ, Anton-Sales I, Loiola RA, Llop J, Ramos-Cabrer P, Barba I, Garcia-Dorado D, Gosselet F, Rosell A, Roig A.

Nanoscale. 2020 Feb 14.

Lien vers article : 32057060


Ketone Bodies Promote Amyloid-β1-40 Clearance in a Human in Vitro Blood-Brain Barrier Model.

Versele R, Corsi M, Fuso A, Sevin E, Businaro R, Gosselet F, Fenart L, Candela P.

Int J Mol Sci. 2020 Jan 31;21(3). pii: E934. doi: 10.3390/ijms21030934.

Lien vers article: 32023814


A High Output Method to Isolate Cerebral Pericytes from Mouse.

Mehra A, Dehouck L, Vandenhaute E, Fatar M, Fenart L, Gosselet F.

J Vis Exp. 2020 Jan 14;(155). doi: 10.3791/60588.

Lien vers article: 32009659


Human CD4+ T-cell subsets differ in their abilities to cross endothelial and epithelial brain barriers in vitro

Nishihara H, Soldati S, Mossu A, Rosito M, Rudolph H, Muller WA, Latorre D, Sallusto F, Sospedra M, Martin R, Ishikawa H, Tenenbaum T, Schroten H, Gosselet F, Engelhardt B

Fluids Barriers CNS. 2020 Feb 3;17(1):3. doi: 10.1186/s12987-019-0165-2.

Lien vers article: 32008573


Non-ionotropic action of endothelial NMDA receptors on blood-brain barrier permeability via Rho/ROCK mediated phosphorylation of myosin.

Mehra A, Guérit S, Macrez R, Gosselet F, Sevin E, Lebas H, Maubert E, De Vries HE, Bardou I, Vivien D, Docagne F.

J Neurosci. 2020 Jan 16. pii: 0969-19. doi: 10.1523/JNEUROSCI.0969-19.2019. [Epub ahead of print]

Lien vers article: 31953371