Publications

2021

Endothelial Iron Homeostasis Regulates Blood-Brain Barrier Integrity via the HIF2α-Ve-Cadherin Pathway.

Rand D, Ravid O, Atrakchi D, Israelov H, Bresler Y, Shemesh C, Omesi L, Liraz-Zaltsman S, Gosselet F, Maskrey TS, Beeri MS, Wipf P, Cooper I.

Pharmaceutics. 2021 Feb 28;13(3):311.

PMID: 33670876

 

Discovery of pyrazolo-thieno[3,2-d]pyrimidinylamino-phenyl acetamides as type-II pan-tropomyosin receptor kinase (TRK) inhibitors: Design, synthesis, and biological evaluation.

Yan W, Zhang L, Lv F, Moccia M, Carlomagno F, Landry C, Santoro M, Gosselet F, Frett B, Li HY.

Eur J Med Chem. 2021 Feb 9;216:113265.

PMID: 33652352

 

Evaluation of a human iPSC-derived BBB model for repeated dose toxicity testing with cyclosporine A as model compound.

Wellens S, Dehouck L, Chandrasekaran V, Singh P, Loiola RA, Sevin E, Exner T, Paul J, Gosselet F, Culot M.

Toxicol In Vitro. 2021 Feb 22:105112.

PMID: 33631201

 

Flow induces barrier and glycocalyx-related genes and negative surface charge in a lab-on-a-chip human blood-brain barrier model.

Santa-Maria AR, Walter FR, Figueiredo R, Kincses A, Vigh JP, Heymans M, Culot M, Winter P, Gosselet F, Dér A, Deli MA.

J Cereb Blood Flow Metab. 2021 Feb 9:271678X21992638.

PMID: 33563079

 

Time-Dependent Internalization of Polymer-Coated Silica Nanoparticles in Brain Endothelial Cells and Morphological and Functional Effects on the Blood-Brain Barrier.

Bittner A, Gosselet F, Sevin E, Dehouck L, Ducray AD, Gaschen V, Stoffel MH, Cho H, Mevissen M.

Int J Mol Sci. 2021 Feb 6;22(4):1657.

PMID: 33562136

 

Beyond the Rule of 5: Impact of PEGylation with Various Polymer Sizes on Pharmacokinetic Properties, Structure-Properties Relationships of mPEGylated Small Agonists of TGR5 Receptor.

Hoguet V, Lasalle M, Maingot M, Dequirez G, Boulahjar R, Leroux F, Piveteau C, Herledan A, Biela A, Dumont J, Chávez-Talavera O, Belloy L, Duplan I, Hennuyer N, Butruille L, Lestavel S, Sevin E, Culot M, Gosselet F, Staels B, Deprez B, Tailleux A, Charton J.

J Med Chem. 2021 Jan 20

PMID: 33470812

 

Differential neurovirulence of Usutu virus lineages in mice and neuronal cells.

Clé M, Constant O, Barthelemy J, Desmetz C, Martin MF, Lapeyre L, Cadar D, Savini G, Teodori L, Monaco F, Schmidt-Chanasit J, Saiz JC, Gonzales G, Lecollinet S, Beck C, Gosselet F, Van de Perre P, Foulongne V, Salinas S, Simonin Y.

J Neuroinflammation. 2021 Jan 6;18(1):11.

PMID: 33407600

 

Central nervous system delivery of molecules across the blood-brain barrier.

Gosselet F, Loiola RA, Roig A, Rosell A, Culot M.

Neurochem Int. 2021 Jan 2:104952.

PMID: 33400964