Discovery, Structure-Activity Relationships, and In Vivo Activity of Dihydropyridone Agonists of the Bile Acid Receptor TGR5.

Picon S, Boulahjar R, Hoguet V, Baron M, Duplan I, Vallez E, Hennuyer N, Dumont J, Touche V, Dorchies E, Lasalle M, Descat A, Piveteau C, Biela A, Chaput L, Villoutreix BO, Lipka E, Sevin E, Culot M, Gosselet F, Lestavel S, Roussel P, Deprez-Poulain R, Leroux F, Staels B, Deprez B, Tailleux A, Charton J.

J Med Chem. 2023 Aug 28.

PMID: 37639383

DOI: 10.1021/acs.jmedchem.2c01881


Predicting human neurotoxicity of propylene glycol methyl ether (PGME) by implementing in vitro neurotoxicity results into toxicokinetic modelling.

Reale E, Sandstrom J, Culot M, Hechon J, Wellens S, Heymans M, Tschudi-Monnet F, Vernez D, Hopf NB.

Sci Total Environ. Sci Total Environ. 2023 Aug 15;886:163767.

PMID: 37156387

DOI: 10.1016/j.scitotenv.2023.163767


Differential Blood-Brain Barrier Transport and Cell Uptake of Cyclic Peptides In Vivo and In Vitro.

Melander E, Eriksson C, Wellens S, Hosseini K, Fredriksson R, Gosselet F, Culot M, Göransson U, Hammarlund-Udenaes M, Loryan I.

Pharmaceutics. 2023 May 16;15(5):1507.

PMID: 37242750

DOI: 10.3390/pharmaceutics15051507


Challenges and Opportunities in the Oral Delivery of Recombinant Biologics.

Masloh S, Culot M, Gosselet F, Chevrel A, Scapozza L, Zeisser Labouebe M.

Pharmaceutics. 2023 May 5;15(5):1415.

PMID: 37242657

DOI: 10.3390/pharmaceutics15051415


High levels of endothelial ICAM-1 prohibit natalizumab mediated abrogation of CD4+ T cell arrest on the inflamed BBB under flow in vitro.

Soldati S, Bär A, Vladymyrov M, Glavin D, McGrath JL, Gosselet F, Nishihara H, Goelz S, Engelhardt B.

J Neuroinflammation. 2023 May 23;20(1):123.

PMID: 37221552

DOI: 10.1186/s12974-023-02797-8


Highlighting In Vitro the Role of Brain-like Endothelial Cells on the Maturation and Metabolism of Brain Pericytes by SWATH Proteomics.

Menaceur C, Hachani J, Dib S, Duban-Deweer S, Karamanos Y, Shimizu F, Kanda T, Gosselet F, Fenart L, Saint-Pol J.

Cells. 2023 Mar 25;12(7):1010.

PMID: 37048083

DOI: 10.3390/cells12071010


Impact of Pesticide Residues on the Gut-Microbiota-Blood-Brain Barrier Axis: A Narrative Review.

Abou Diwan M, Lahimer M, Bach V, Gosselet F, Khorsi-Cauet H, Candela P.

Int J Mol Sci. 2023 Mar 24;24(7):6147.

PMID: 37047120

DOI: 10.3390/ijms24076147


TNFα Activates the Liver X Receptor Signaling Pathway and Promotes Cholesterol Efflux from Human Brain Pericytes Independently of ABCA1.

Dib S, Loiola RA, Sevin E, Saint-Pol J, Shimizu F, Kanda T, Pahnke J, Gosselet F.

Int J Mol Sci. 2023 Mar 22;24(6):5992.

PMID: 36983062

DOI: 10.3390/ijms24065992.